Sometimes when you’re troubleshooting, it’s a good idea to check the environment in which Softimage is running.
You can check specific environment variables in the script editor like this:

import os
print os.getenv( "XSI_USERHOME" )
print os.getenv( "TEMP" )

or like this:

print XSIUtils.Environment("XSI_BINDIR")

But I would typically use Process Explorer to see the full environment:

or Process Monitor (in Process Monitor, you just have to find the Process Start operation for XSI.exe and double-click it).